Methods Chloroacetic acid was treated with thionyl chloride, amines and triphenylphosphine to provide quaternary phosphonium salts, which were treated with phthalic anhydride to get the target compounds by the Wittig reaction. The pure products were obtained by silica gel column chromatography. 方法以氯乙酸为起始原料,依次与氯化亚砜、胺、三苯膦反应制得季磷盐,再与邻苯二甲酸酐经Wittig反应制得目标化合物,硅胶柱色谱得纯品。
Innovation on process of chloroacetic acid by acetic anhydride method was introduced. 介绍了醋酐法氯乙酸生产工艺的改进。